Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives

Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives

NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a series of new derivatives of NAG-thiazoline modified at the C-6 position. Dimerization of NAG-thiazoline via...

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Bibliographic Details
Main Authors: Jana Krejzová, Petr Šimon, Lubica Kalachova, Natallia Kulik, Pavla Bojarová, Petr Marhol, Helena Pelantová, Josef Cvačka, Rüdiger Ettrich, Kristýna Slámová, Vladimír Křen
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Molecules
Subjects:
NAG-thiazoline
enzyme inhibition
O-GlcNAcase
click chemistry
azide
β-N-acetylhexosaminidase
Online Access:http://www.mdpi.com/1420-3049/19/3/3471

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http://www.mdpi.com/1420-3049/19/3/3471

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