Contrasting In Vivo Effects of Two Peptide-Based Amyloid-β Protein Aggregation Inhibitors in a Transgenic Mouse Model of Amyloid Deposition
Previous studies have shown that 17,19,21-tri-N-methyl-Aβ16-22 peptide (Aβ16-22m), and a peptide analogue containing α,α-disubsituted amino acids (ααAA) in the hydrophobic core domain of Aβ, termed AMY-1, effectively inhibited full-length Aβ aggregation in vitro. To investigate the amyloid-modifying...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2008-04-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/096368908784423247 |