Infection of sympathetic and sensory neurones with herpes simplex virus does not elicit a shut-off of cellular protein synthesis: implications for viral latency and herpes vectors

Infection of sympathetic and sensory neurones with herpes simplex virus does not elicit a shut-off of cellular protein synthesis: implications for viral latency and herpes vectors

Infection of non-neuronal cell types with herpes simplex virus type 1 (HSV-1) results in the degradation of host mRNA (Kwong & Frenkel 1987) and a shutoff in host protein synthesis (Roizmanet al.1965). This effect is mediated by a virion associated protein that is encoded by the viralvhsgene...

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Bibliographic Details
Main Authors: Peter F. Nichol, Jason Y. Chang, Eugene M. Johnson, Jr, Paul D. Olivo
Format: Article
Language:English
Published: Elsevier 1994-11-01
Series:Neurobiology of Disease
Subjects:
expression vectors
herpes simplex virus
latency
sensory neurones
sympathetic neurones
virion host shut-off
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996184700118

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http://www.sciencedirect.com/science/article/pii/S0969996184700118

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