Autophagy Functions to Prevent Methylglyoxal-Induced Apoptosis in HK-2 Cells

Methylglyoxal (MGO), a reactive carbonyl species, causes cellular damage and is closely related to kidney disease, particularly diabetic nephropathy. Although MGO has been reported to induce autophagy and apoptosis, the relationships between the two pathways are unclear. Here, we evaluated whether a...

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Bibliographic Details
Main Authors: So-Hyun Park, Hyun-Il Choi, Jiyun Ahn, Young-Jin Jang, Tae-Youl Ha, Hyo-Deok Seo, Yoon-Sook Kim, Dae-Hee Lee, Chang Hwa Jung
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/8340695