Identification of the Biosynthetic Gene Cluster of Thermoactinoamides and Discovery of New Congeners by Integrated Genome Mining and MS-Based Molecular Networking

Identification of the Biosynthetic Gene Cluster of Thermoactinoamides and Discovery of New Congeners by Integrated Genome Mining and MS-Based Molecular Networking

The putative non-ribosomal peptide synthetase (NRPS) gene cluster encoding the biosynthesis of the bioactive cyclohexapeptide thermoactinoamide A (1) was identified in Thermoactinomyces vulgaris DSM 43016. Based on an in silico prediction, the biosynthetic operon was shown to contain two trimodular...

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Bibliographic Details
Main Authors: Gerardo Della Sala, Alfonso Mangoni, Valeria Costantino, Roberta Teta
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Chemistry
Subjects:
genome mining
non-ribosomal peptides
molecular networking
metabolomics
antiproliferative activity
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00397/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00397/full

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