Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.
We present a data-driven mathematical model of a key initiating step in platelet activation, a central process in the prevention of bleeding following Injury. In vascular disease, this process is activated inappropriately and causes thrombosis, heart attacks and stroke. The collagen receptor GPVI is...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-11-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC4652868?pdf=render |