Down-regulation of miR-126 is associated with colorectal cancer cells proliferation, migration and invasion by targeting IRS-1 via the AKT and ERK1/2 signaling pathways.

Down-regulation of miR-126 is associated with colorectal cancer cells proliferation, migration and invasion by targeting IRS-1 via the AKT and ERK1/2 signaling pathways.

Colorectal carcinoma (CRC) is one of the leading causes of cancer-related mortality worldwide. MicroRNAs (miRNAs, miRs) play important roles in carcinogenesis. MiR-126 has been shown to be down-regulated in CRC. In this study, we identified the potential effects of miR-126 on some important biologic...

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Bibliographic Details
Main Authors: Yu Zhou, Xiao Feng, Ya-ling Liu, Shi-cai Ye, Hao Wang, Wen-kai Tan, Ting Tian, Yu-mei Qiu, He-sheng Luo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3843680?pdf=render

Internet

http://europepmc.org/articles/PMC3843680?pdf=render

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