Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS

Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS

Abstract Background Microglia, the primary resident myeloid cells of the brain, play critical roles in immune defense by maintaining tissue homeostasis and responding to injury or disease. However, microglial activation and dysfunction has been implicated in a number of central nervous system (CNS)...

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Bibliographic Details
Main Authors: Lindsay A. Hohsfield, Allison R. Najafi, Yasamine Ghorbanian, Neelakshi Soni, Edna E. Hingco, Sung Jin Kim, Ayer Darling Jue, Vivek Swarup, Mathew A. Inlay, Kim N. Green
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Monocytes
CSF1R inhibition
Irradiation
Bone marrow transplant
Brain
Online Access:http://link.springer.com/article/10.1186/s12974-020-01931-0

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http://link.springer.com/article/10.1186/s12974-020-01931-0

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