Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux.

Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux.

Pax3cre-mediated deletion of fibroblast growth factor receptor 2 (Fgfr2) broadly in renal and urinary tract mesenchyme led to ureteric bud (UB) induction defects and vesicoureteral reflux (VUR), although the mechanisms were unclear. Here, we investigated whether Fgfr2 acts specifically in peri-Wolff...

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Bibliographic Details
Main Authors: Kenneth A Walker, Sunder Sims-Lucas, Valeria E Di Giovanni, Caitlin Schaefer, Whitney M Sunseri, Tatiana Novitskaya, Mark P de Caestecker, Feng Chen, Carlton M Bates
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3567073?pdf=render

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http://europepmc.org/articles/PMC3567073?pdf=render

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