Selective HDAC8 Inhibition Attenuates Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis via p38 MAPK Pathway

Selective HDAC8 Inhibition Attenuates Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis via p38 MAPK Pathway

Histone deacetylase (HDAC) expression and enzymatic activity are dysregulated in cardiovascular diseases. Among Class I HDACs, HDAC2 has been reported to play a key role in cardiac hypertrophy; however, the exact function of HDAC8 remains unknown. Here we investigated the role of HDAC8 in cardiac hy...

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Bibliographic Details
Main Authors: Tingwei Zhao, Hae Jin Kee, Liyan Bai, Moon-Ki Kim, Seung-Jung Kee, Myung Ho Jeong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
histone deacetylase8
PCI34051
cardiac hypertrophy
fibrosis
p38MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.677757/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.677757/full

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