Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Osteoblasts mediate bone formation, and their differentiation requires expression of EphrinB2. Here, the authors show that EphrinB2 is also expressed by osteocytes, and that its genetic ablation in mice is associated with altered autophagy, elevated mineralization and brittle bone.

Bibliographic Details
Main Authors: Christina Vrahnas, Martha Blank, Toby A. Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Huynh Nguyen, Mark R. Forwood, Yifang Hu, Mika Ikegame, Keith R. Bambery, Cyril Petibois, Eleanor J. Mackie, Mark J. Tobin, Gordon K. Smyth, Jonathan S. Oakhill, T. John Martin, Natalie A. Sims
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11373-9

Internet

https://doi.org/10.1038/s41467-019-11373-9

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