A Recurrent Cryptic MED14-HOXA9 Rearrangement in an Adult Patient With Mixed-Phenotype Acute Leukemia, T/myeloid, NOS

A Recurrent Cryptic MED14-HOXA9 Rearrangement in an Adult Patient With Mixed-Phenotype Acute Leukemia, T/myeloid, NOS

To define the fusion genes in T/myeloid mixed-phenotype acute leukemia (T/M MPAL), we performed transcriptome sequencing of diagnostic bone marrow samples from 20 adult patients. Our analysis identified a second instance of a recurrent MED14-HOXA9 chimeric gene resulting from the in-frame fusion of...

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Bibliographic Details
Main Authors: Qian Wang, Ling Zhang, Ming-qing Zhu, Zhao Zeng, Bao-zhi Fang, Jun-dan Xie, Jin-lan Pan, Chun-xiao Wu, Ni Wu, Ri Zhang, Su-ning Chen, Hai-ping Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
mixed-phenotype acute leukemia
MED14-HOXA9
fusion gene
PTPN11
NOTCH1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.690218/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.690218/full

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