Tractography of the brainstem in major depressive disorder using diffusion tensor imaging.

BACKGROUND: The brainstem is the main region that innervates neurotransmitter release to the Hypothalamic-Pituitary Adrenal (HPA) axis and fronto-limbic circuits, two key brain circuits found to be dysfunctional in Major Depressive Disorder (MDD). However, the brainstem's role in MDD has only b...

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Bibliographic Details
Main Authors: Yun Ju C Song, Mayuresh S Korgaonkar, Lucy V Armstrong, Sarah Eagles, Leanne M Williams, Stuart M Grieve
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897382?pdf=render