Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.

Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.

Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease despite the availability of chemotherapy and BCG vaccine. The commonly used avirulent M. tuberculosis strain H37Ra was derived from virulent strain H37 in 1935 but the basis of virulence attenuation has remained...

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Bibliographic Details
Main Authors: Huajun Zheng, Liangdong Lu, Bofei Wang, Shiying Pu, Xianglin Zhang, Genfeng Zhu, Wanliang Shi, Lu Zhang, Honghai Wang, Shengyue Wang, Guoping Zhao, Ying Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2440308?pdf=render

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http://europepmc.org/articles/PMC2440308?pdf=render

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