Genetic effects on promoter usage are highly context-specific and contribute to complex traits

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

Genetic variants regulating RNA splicing and transcript usage have been implicated in both common and rare diseases. Although transcript usage quantitative trait loci (tuQTLs) have been mapped across multiple cell types and contexts, it is challenging to distinguish between the main molecular mechan...

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Bibliographic Details
Main Authors: Kaur Alasoo, Julia Rodrigues, John Danesh, Daniel F Freitag, Dirk S Paul, Daniel J Gaffney
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
splicing
RNA-seq
macrophages
genetics
transcription
Online Access:https://elifesciences.org/articles/41673

Internet

https://elifesciences.org/articles/41673

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