Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase

Summary: The insulin receptor substrate IRS-1 is a key substrate of insulin and insulin-like growth factor (IGF) receptor tyrosine kinases that mediates their metabolic and growth-promoting actions. Proteasomal degradation of IRS-1 is induced following activation of the downstream kinase mTOR comple...

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Bibliographic Details
Main Authors: Yosuke Yoneyama, Tomomi Inamitsu, Kazuhiro Chida, Shun-Ichiro Iemura, Tohru Natsume, Tatsuya Maeda, Fumihiko Hakuno, Shin-Ichiro Takahashi
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300828

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http://www.sciencedirect.com/science/article/pii/S2589004218300828

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