Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

Notch signaling is an important regulator of stem cell differentiation. All canonical Notch signaling is transmitted through the DNA-binding protein CSL, and hyperactivated Notch signaling is associated with tumor development; thus it may be anticipated that CSL deficiency should reduce tumor growth...

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Bibliographic Details
Main Authors: Eike-Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Sebastian Landor, Helena Silva Cascales, Daniel Ramsköld, Qiaolin Deng, Arne Lindqvist, Xiaojun Lian, Cecilia Sahlgren, Shao-Bo Jin, Urban Lendahl
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Stem Cell Reports
Subjects:
breast cancer
Notch signaling
xenograft
transcriptome
mitosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116000850

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http://www.sciencedirect.com/science/article/pii/S2213671116000850

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