Preventing Aggregation of Recombinant Interferon beta-1b in Solution by Additives: Approach to an Albumin-Free Formulation

Preventing Aggregation of Recombinant Interferon beta-1b in Solution by Additives: Approach to an Albumin-Free Formulation

Purpose: Aggregation suppressing additives have been used to stabilize proteins during manufacturing and storage. Interferonβ-1b is prone to aggregation because of being non-glycosylated. Aggregation behavior of albumin-free formulations of recombinant IFNβ-1b was explored using additives such as n-...

Full description

Bibliographic Details
Main Authors: Najmeh Mahjoubi, Mohammad Reza Fazeli, Rassoul Dinarvand, Mohammad Reza Khoshayand, Ahmad Fazeli, Mohammad Taghavian, Hossein Rastegar
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2015-11-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
n-Dodecyl-β-D-maltoside
Optimization
HSA-free formulation
Aggregation
Box-Behnken experimental design
Online Access:http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-497.pdf

Internet

http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-497.pdf

Similar Items