Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (I...

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Bibliographic Details
Main Authors: Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
Alzheimer’s disease
quinazolinones
multicomponent reactions
multitarget-directed ligands
antioxidants
cholinesterase inhibitors
hepatotoxicity
Online Access:http://www.mdpi.com/1420-3049/21/5/634

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http://www.mdpi.com/1420-3049/21/5/634

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