Epigenetic silencing of CD4 expression in nonpathogenic SIV infection in African green monkeys

Epigenetic silencing of CD4 expression in nonpathogenic SIV infection in African green monkeys

African green monkeys (AGMs) are natural hosts of SIV that postthymically downregulate CD4 to maintain a large population of CD4–CD8aa+ virus-resistant cells with Th functionality, which can result in AGMs becoming apparently cured of SIVagm infection. To understand the mechanisms of this process, w...

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Bibliographic Details
Main Authors: Joseph C. Mudd, Stephen Lai, Sanjana Shah, Andrew Rahmberg, Jacob K. Flynn, Carly E. Starke, Molly R. Perkins, Amy Ransier, Sam Darko, Daniel C. Douek, Vanessa M. Hirsch, Mark Cameron, Jason M. Brenchley
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-09-01
Series:JCI Insight
Subjects:
AIDS/HIV
Immunology
Online Access:https://doi.org/10.1172/jci.insight.139043

Internet

https://doi.org/10.1172/jci.insight.139043

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