Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/<it>neu </it>single chain Fv for use in ADEPT

Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/<it>neu </it>single chain Fv for use in ADEPT

<p>Abstract</p> <p>Background</p> <p>Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT. However, these non-human enzymes are immunogenic limiting the...

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Bibliographic Details
Main Authors: Wu Anna M, Olafsen Tove, Afshar Sepideh, Morrison Sherie L
Format: Article
Language:English
Published: BMC 2009-12-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:http://www.jeccr.com/content/28/1/147

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http://www.jeccr.com/content/28/1/147

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