CD9+ Regulatory B Cells Induce T Cell Apoptosis via IL-10 and Are Reduced in Severe Asthmatic Patients

CD9+ Regulatory B Cells Induce T Cell Apoptosis via IL-10 and Are Reduced in Severe Asthmatic Patients

CD9 was recently identified as a marker of murine IL-10-competent regulatory B cells. Functional impairments or defects in CD9+ IL-10-secreting regulatory B cells are associated with enhanced asthma-like inflammation and airway hyperresponsiveness. In mouse models, all asthma-related features can be...

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Bibliographic Details
Main Authors: Carole Brosseau, Maxim Durand, Luc Colas, Eugénie Durand, Aurore Foureau, Marie-Aude Cheminant, Gregory Bouchaud, Laure Castan, Martin Klein, Antoine Magnan, Sophie Brouard
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
regulatory B cells
CD9+ B cells
severe asthma
apoptosis
effector T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03034/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03034/full

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