Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats

Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats

Abstract Background Post-ischemic inflammation is a crucial component in stroke pathology in the early phase of cerebral ischemia–reperfusion (I/R) injury. Inflammation caused by microglia, astrocytes, and necrotic cells, produces pro-inflammatory mediators and exacerbates cerebral I/R injury. This...

Full description

Bibliographic Details
Main Authors: Chin-Yi Cheng, Su-yin Chiang, Shung-Te Kao, Shang-Chih Huang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Chinese Medicine
Subjects:
Alpinia oxyphylla Miq
Ischemia
Reperfusion
c-Jun N-terminal kinase
Toll-like receptor 4
TRAF3-interacting JNK-activating modulator
Online Access:https://doi.org/10.1186/s13020-021-00495-2

Internet

https://doi.org/10.1186/s13020-021-00495-2

Similar Items