Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression

Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression

Abstract Background Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fibroblast proliferation and prevent collagen synthesis. Results High dose...

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Bibliographic Details
Main Authors: Qiang Chen, Jiuyang Jiao, Youyuan Wang, Zhihui Mai, Jing Ren, Sijie He, Xiaolan Li, Zheng Chen
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Molecular and Cell Biology
Subjects:
Arecoline
Wnt5a
Egr-1
Fibrosis
Oral submucous fibroblast
Online Access:http://link.springer.com/article/10.1186/s12860-020-00325-7

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http://link.springer.com/article/10.1186/s12860-020-00325-7

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