Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model

Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model

Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a small subset of patients, partly because of the lack of sufficient immune cells in the tumor. It is reported that targeted lactate dehydrogenase (LDH) to reduce lactic acid production can promote the infilt...

Full description

Bibliographic Details
Main Authors: Tianyun Qiao, Yanlu Xiong, Yangbo Feng, Wenwen Guo, Yongsheng Zhou, Jinbo Zhao, Tao Jiang, Changhong Shi, Yong Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
NSCLC
immunotherapy
anti-PD-1
oxamate
LDH
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.632364/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.632364/full

Similar Items