Differential Effects of Indoxyl Sulfate and Inorganic Phosphate in a Murine Cerebral Endothelial Cell Line (bEnd.3)

Differential Effects of Indoxyl Sulfate and Inorganic Phosphate in a Murine Cerebral Endothelial Cell Line (bEnd.3)

Endothelial dysfunction plays a key role in stroke in chronic kidney disease patients. To explore the underlying mechanisms, we evaluated the effects of two uremic toxins on cerebral endothelium function. bEnd.3 cells were exposed to indoxyl sulfate (IS) and inorganic phosphate (Pi). Nitric oxide (N...

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Bibliographic Details
Main Authors: Andréa E. M. Stinghen, Jean-Marc Chillon, Ziad A. Massy, Agnès Boullier
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Toxins
Subjects:
chronic kidney disease
uremic toxins
endothelial dysfunction
nitric oxide
reactive oxygen species
Online Access:http://www.mdpi.com/2072-6651/6/6/1742

Internet

http://www.mdpi.com/2072-6651/6/6/1742

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