Mutations of Cx43 that affect B cell spreading in response to BCR signaling

Mutations of Cx43 that affect B cell spreading in response to BCR signaling

The gap junction (GJ) protein connexin 43 (Cx43) is both necessary and sufficient for B cell receptor (BCR)-mediated cell spreading. To address how Cx43 mediates this effect, we blocked its function genetically, by expressing mutants of Cx43, and pharmacologically, by using chemical inhibitors. Whil...

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Bibliographic Details
Main Authors: Letitia Falk, May Dang-Lawson, José Luis Vega, Farnaz Pournia, Kate Choi, Caren Jang, Christian C. Naus, Linda Matsuuchi
Format: Article
Language:English
Published: The Company of Biologists 2014-07-01
Series:Biology Open
Subjects:
B cell
B cell receptor
BCR
Cx43
Connexin 43
Hemichannel
Gap junction protein
Online Access:http://bio.biologists.org/content/3/3/185

Internet

http://bio.biologists.org/content/3/3/185

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