The mechanism of monomer transfer between two structurally distinct PrP oligomers.

In mammals, Prion pathology refers to a class of infectious neuropathologies whose mechanism is based on the self-perpetuation of structural information stored in the pathological conformer. The characterisation of the PrP folding landscape has revealed the existence of a plethora of pathways conduc...

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Bibliographic Details
Main Authors: Aurora Armiento, Philippe Moireau, Davy Martin, Nad'a Lepejova, Marie Doumic, Human Rezaei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5528842?pdf=render