Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria

Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria

The most advanced malaria vaccine, RTS,S, includes the central repeat and C-terminal domains of the <i>Plasmodium falciparum</i> circumsporozoite protein (PfCSP). We have recently isolated human antibodies that target the junctional region between the N-terminal and repeat domains that a...

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Bibliographic Details
Main Authors: Joseph R. Francica, Wei Shi, Gwo-Yu Chuang, Steven J. Chen, Lais Da Silva Pereira, S. Katie Farney, Barbara J. Flynn, Li Ou, Tyler Stephens, Yaroslav Tsybovsky, Lawrence T. Wang, Alexander Anderson, Zoltan Beck, Marlon Dillon, Azza H. Idris, Nicholas Hurlburt, Tracy Liu, Baoshan Zhang, Carl R. Alving, Gary R. Matyas, Marie Pancera, John R. Mascola, Peter D. Kwong, Robert A. Seder
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Vaccines
Subjects:
junctional epitope
malaria
neutralizing antibodies
parasite
<i>Plasmodium falciparum</i>
vaccines
Online Access:https://www.mdpi.com/2076-393X/9/3/272

Internet

https://www.mdpi.com/2076-393X/9/3/272

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