Long-Term Remission Achieved by Ponatinib and Donor Lymphocytes Infusion in a Ph+ Acute Lymphoblastic Leukemia Patient in Molecular Relapse After Allogenic Stem Cell Transplant and Dasatinib: A Case Report

Long-Term Remission Achieved by Ponatinib and Donor Lymphocytes Infusion in a Ph+ Acute Lymphoblastic Leukemia Patient in Molecular Relapse After Allogenic Stem Cell Transplant and Dasatinib: A Case Report

Currently, the prognosis of Ph+ acute lymphoblastic leukemia (Ph+ ALL) patients relapsing after an allogenic hematopoietic stem cell transplantation (allo-SCT) remains poor, with few therapeutic options available. Here we present the case of a 32 years old patient with dasatinib-resistant post-trans...

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Bibliographic Details
Main Authors: Cirino Botta, Nadia Caruso, Sabrina Bossio, Francesca Storino, Giuseppe Console, Massimo Martino, Francesco Mendicino, Eugenio Lucia, Rosellina Morelli, Pierpaolo Correale, Fortunato Morabito, Massimo Gentile, Ernesto Vigna
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
T lymphocytes
donor lymphocyte infusion (DLI)
ponatinib
bone marrow microenviroment
acute lymhoblastic leukemia
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00967/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00967/full

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