Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure.

Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure.

Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubular sclerosis complex 2 (Tsc2) knockout mouse model (Tsc2Δpodocyte) develops proteinuria and dies due...

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Bibliographic Details
Main Authors: Wakiko Iwata, Hiroyuki Unoki-Kubota, Hideki Kato, Akira Shimizu, Michihiro Matsumoto, Toshiyuki Imasawa, Arisa Igarashi, Kenji Matsumoto, Tetsuo Noda, Yasuo Terauchi, Masaomi Nangaku, Masato Kasuga, Yasushi Kaburagi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229397

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https://doi.org/10.1371/journal.pone.0229397

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