Cellular Genomic Sites of Hepatitis B Virus DNA Integration

Cellular Genomic Sites of Hepatitis B Virus DNA Integration

Infection with the Hepatitis B Virus (HBV) is one of the strongest risk-factors for liver cancer (hepatocellular carcinoma, HCC). One of the reported drivers of HCC is the integration of HBV DNA into the host cell genome, which may induce pro-carcinogenic pathways. These reported pathways include: i...

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Bibliographic Details
Main Authors: Magdalena A. Budzinska, Nicholas A. Shackel, Stephan Urban, Thomas Tu
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Genes
Subjects:
Hepatitis B Virus
hepatocellular carcinoma (HCC)
next generation sequencing
inverse nested PCR
chromosomal instability
insertional mutagenesis
non-homologous end joining
cancer evolution
clonal expansion
viral persistence
Online Access:http://www.mdpi.com/2073-4425/9/7/365

Internet

http://www.mdpi.com/2073-4425/9/7/365

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