Evolution of a Novel Antiviral Immune-Signaling Interaction by Partial-Gene Duplication.

The RIG-like receptors (RLRs) are related proteins that identify viral RNA in the cytoplasm and activate cellular immune responses, primarily through direct protein-protein interactions with the signal transducer, IPS1. Although it has been well established that the RLRs, RIG-I and MDA5, activate IP...

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Bibliographic Details
Main Authors: Bryan Korithoski, Oralia Kolaczkowski, Krishanu Mukherjee, Reema Kola, Chandra Earl, Bryan Kolaczkowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4565553?pdf=render