Keeping Cell Death in Check: Ubiquitylation-Dependent Control of TNFR1 and TLR Signaling

Keeping Cell Death in Check: Ubiquitylation-Dependent Control of TNFR1 and TLR Signaling

Pro-inflammatory signaling pathways, induced by pathogens, tissue damage or cytokines, depend on the ubiquitylation of various subunits of receptor signaling complexes, controlled by ubiquitin ligases and deubiquitinases. Ubiquitylation sets the stage for the activation of kinases within these recep...

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Bibliographic Details
Main Authors: Laura Griewahn, Aaron Köser, Ulrich Maurer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TLR
TNFR1
TNF
ubiquitin
inflammation
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00117/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00117/full

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