Parameters Affecting Image-guided, Hydrodynamic Gene Delivery to Swine Liver

Parameters Affecting Image-guided, Hydrodynamic Gene Delivery to Swine Liver

Development of a safe and effective method for gene delivery to hepatocytes is a critical step toward gene therapy for liver diseases. Here, we assessed the parameters for gene delivery to the livers of large animals (pigs, 40–65 kg) using an image-guided hydrodynamics-based procedure that involves...

Full description

Bibliographic Details
Main Authors: Kenya Kamimura, Takeshi Suda, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gene therapy
human α-1 antitrypsin
hydrodynamic gene delivery
image-guided gene delivery
non-viral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301846

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116301846

Similar Items