Hippocampal neurons in direct contact with astrocytes exposed to amyloid β25-35 exhibit reduced excitatory synaptic transmission

Amyloid β protein (Aβ) is closely related to the progression of Alzheimer's disease because senile plaques consisting of Aβ cause synaptic depression and synaptic abnormalities. In the central nervous system, astrocytes are a major glial cell type that contribute to the modulation of synaptic t...

Full description

Bibliographic Details
Main Authors: Kohei Oyabu, Hiroki Kiyota, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:IBRO Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2451830119317716