Concentration-dependent alpha1-Adrenoceptor Antagonism and Inhibition of Neurogenic Smooth Muscle Contraction by Mirabegron in the Human Prostate

Concentration-dependent alpha1-Adrenoceptor Antagonism and Inhibition of Neurogenic Smooth Muscle Contraction by Mirabegron in the Human Prostate

Introduction: Mirabegron is available for treatment of storage symptoms in overactive bladder, which may be improved by β3-adrenoceptor-induced bladder smooth muscle relaxation. In addition to storage symptoms, lower urinary tract symptoms in men include obstructive symptoms attributed to benign pro...

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Bibliographic Details
Main Authors: Ru Huang, Yuhan Liu, Anna Ciotkowska, Alexander Tamalunas, Raphaela Waidelich, Frank Strittmatter, Christian G. Stief, Martin Hennenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
mirabegron
lower urinary tract symptoms (LUTS)
benign prostatic hyperplasia (BPH)
obstructive symptoms
bladder outlet obstruction (BOO)
prostate smooth muscle contraction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.666047/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.666047/full

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