Wild-Type IDH Enzymes as Actionable Targets for Cancer Therapy
Isocitrate dehydrogenases (IDHs) are enzymes that catalyze the oxidative decarboxylation of isocitrate, producing α-ketoglutarate (αKG) and CO<sub>2</sub>. The discovery of IDH1 and IDH2 mutations in several malignancies has brought to the approval of drugs targeting ID...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/4/563 |