Activation of the Adipose Tissue NLRP3 Inflammasome Pathway in Cancer Cachexia

Activation of the Adipose Tissue NLRP3 Inflammasome Pathway in Cancer Cachexia

BackgroundCachexia is a paraneoplastic syndrome that accompanies and compromises cancer treatment, especially in advanced stages, affecting the metabolism and function of several organs. The adipose tissue is the first to respond to the presence of the tumor, contributing to the secretion of factors...

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Main Authors: Joyce de Cassia Rosa de Jesus, Ariene Soares de Pinho Murari, Katrin Radloff, Ruan Carlos Macêdo de Moraes, Raquel Galvão Figuerêdo, Ana Flavia Marçal Pessoa, José César Rosa-Neto, Emídio Marques Matos-Neto, Paulo S. M. Alcântara, Flavio Tokeshi, Linda Ferreira Maximiano, Fang Chia Bin, Fernanda Bellotti Formiga, José P. Otoch, Marilia Seelaender
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
neoplasms
cachexia
adipose tissue heterogeneity
inflammation
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.729182/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.729182/full

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