Ras-Related Tumorigenesis Is Suppressed by BNIP3-Mediated Autophagy through Inhibition of Cell Proliferation

Autophagy plays diverse roles in Ras-related tumorigenesis. H-rasval12 induces autophagy through multiple signaling pathways including Raf-1/ERK pathway, and various ERK downstream molecules of autophagy have been reported. In this study, Bcl-2/adenovirus E1B 19-kDa–interacting protein 3 (BNIP3) is...

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Bibliographic Details
Main Authors: Shan-Ying Wu, Sheng-Hui Lan, Da-En Cheng, Wei-Kai Chen, Cheng-Huang Shen, Ying-Ray Lee, Roberto Zuchini, Hsiao-Sheng Liu
Format: Article
Language:English
Published: Elsevier 2011-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611801041