Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

Natural killer (NK) cells are innate lymphocytes that play a pivotal role in the immune surveillance and elimination of transformed or virally infected cells. Using a chemo-genetic approach, we identify BET bromodomain containing proteins BRD2 and BRD4 as central regulators of NK cell functions, inc...

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Bibliographic Details
Main Authors: Adam P. Cribbs, Panagis Filippakopoulos, Martin Philpott, Graham Wells, Henry Penn, Henrik Oerum, Viia Valge-Archer, Marc Feldmann, Udo Oppermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
BET bromodomain
BRD2
BRD4
NK cell
epigenetics (DNA methylation histone modifications)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.626255/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.626255/full

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