Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration

Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration

Patients with certain defects in the dehydrodolichyl diphosphate synthase (DHDDS) gene (RP59; OMIM #613861) exhibit classic symptoms of retinitis pigmentosa, as well as macular changes, suggestive of retinal pigment epithelium (RPE) involvement. The DHDDS enzyme is ubiquitously required for several...

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Bibliographic Details
Main Authors: Marci L. DeRamus, Stephanie J. Davis, Sriganesh Ramachandra Rao, Cyril Nyankerh, Delores Stacks, Timothy W. Kraft, Steven J. Fliesler, Steven J. Pittler
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
retinal degeneration
retinitis pigmentosa
retinal pigment epithelium dystrophy
rpe transmigration
cre-lox technology
mouse models
Online Access:https://www.mdpi.com/2073-4409/9/3/771

Internet

https://www.mdpi.com/2073-4409/9/3/771

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