The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria Matters

The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria Matters

BackgroundAlthough the exact pathophysiology of MS has not been identified, mitochondrial stress can be one of the culprits in MS development. Herein, we have applied microarray analysis, single-cell sequencing analysis, and ex vivo study to elucidate the role of mitochondrial stress in PBMCs of MS...

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Bibliographic Details
Main Authors: Afshin Derakhshani, Hossein Safarpour, Mahdi Abdoli Shadbad, Nima Hemmat, Patrizia Leone, Zahra Asadzadeh, Mehrdad Pashazadeh, Behzad Baradaran, Vito Racanelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
mitochondrial injury
oxidative stress
immune cells
peripheral blood mononuclear cells
HBD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.709173/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.709173/full

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