A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy

A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy

Temporal lobe epilepsy (TLE) has a multifactorial etiology involving developmental, environmental, and genetic components. Here, we report a voltage-gated potassium channel gene mutation found in a TLE patient, namely a Kv4.2 truncation mutation. Kv4.2 channels, encoded by the KCND2 gene, mediate A...

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Bibliographic Details
Main Authors: Baljinder Singh, Ikuo Ogiwara, Makoto Kaneda, Natsuko Tokonami, Emi Mazaki, Koichi Baba, Kazumi Matsuda, Yushi Inoue, Kazuhiro Yamakawa
Format: Article
Language:English
Published: Elsevier 2006-11-01
Series:Neurobiology of Disease
Subjects:
Temporal lobe epilepsy
KCND2
Kv4.2
Potassium channel
Truncation mutation
A currents
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001549

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http://www.sciencedirect.com/science/article/pii/S0969996106001549

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