The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution

The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution

CD4+ and CD8+ αβ T cell antigen recognition is determined by the interaction between the TCR Complementarity Determining Region (CDR) loops and the peptide-presenting MHC complex. These T cells are known for their ability to recognize multiple pMHC complexes, and for a necessary promiscuity that is...

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Bibliographic Details
Main Authors: James E. Crooks, Christopher T. Boughter, L. Ridgway Scott, Erin J. Adams
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
molecular dynamics (MD)
markov state models
T cell receptor dynamics
adaptive immunity
innate immunity
independent component (IC) analysis
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2018.00095/full

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https://www.frontiersin.org/article/10.3389/fmolb.2018.00095/full

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