Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

Hepatic stellate cells (HSCs) serve as the main body storage compartment for vitamin A through retinyl ester (RE)-filled lipid droplets (LDs). Upon liver injury, HSCs adopt a myofibroblastic phenotype characterized by an elevated expression of extracellular matrix proteins and a concomitant loss of...

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Bibliographic Details
Main Authors: Marie Bobowski-Gerard, Francesco Paolo Zummo, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cells
Subjects:
liver
hepatic stellate cells
lipid droplet
retinoids
liver injury
intercellular communications
Online Access:http://www.mdpi.com/2073-4409/7/9/137

Internet

http://www.mdpi.com/2073-4409/7/9/137

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