Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural rationale for ligand bias in a nuclear receptor.

Bibliographic Details
Main Authors: Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Scott J. Novick, Anne-Laure Blayo, Trey Patton, Desiree E. Mendes, Philippe Diaz, Theodore M. Kamenecka, Patrick R. Griffin, Travis S. Hughes
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13768-0

Internet

https://doi.org/10.1038/s41467-019-13768-0

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