Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural rationale for ligand bias in a nuclear receptor.
Bibliographic Details
| Main Authors: |
Zahra Heidari,
Ian M. Chrisman,
Michelle D. Nemetchek,
Scott J. Novick,
Anne-Laure Blayo,
Trey Patton,
Desiree E. Mendes,
Philippe Diaz,
Theodore M. Kamenecka,
Patrick R. Griffin,
Travis S. Hughes |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-13768-0
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