Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural rationale for ligand bias in a nuclear receptor.

Bibliographic Details
Main Authors:	Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Scott J. Novick, Anne-Laure Blayo, Trey Patton, Desiree E. Mendes, Philippe Diaz, Theodore M. Kamenecka, Patrick R. Griffin, Travis S. Hughes
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13768-0

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spelling	doaj-27b2fda7dc814baabc2b2a797db6f9452021-05-11T11:30:19ZengNature Publishing GroupNature Communications2041-17232019-12-0110111410.1038/s41467-019-13768-0Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγZahra Heidari0Ian M. Chrisman1Michelle D. Nemetchek2Scott J. Novick3Anne-Laure Blayo4Trey Patton5Desiree E. Mendes6Philippe Diaz7Theodore M. Kamenecka8Patrick R. Griffin9Travis S. Hughes10Department of Biomedical and Pharmaceutical Sciences, University of MontanaCenter for Biomolecular Structure and Dynamics, University of MontanaCenter for Biomolecular Structure and Dynamics, University of MontanaDepartment of Molecular Medicine, The Scripps Research InstituteDepartment of Molecular Medicine, The Scripps Research InstituteDepartment of Biomedical and Pharmaceutical Sciences, University of MontanaDepartment of Biomedical and Pharmaceutical Sciences, University of MontanaDepartment of Biomedical and Pharmaceutical Sciences, University of MontanaDepartment of Molecular Medicine, The Scripps Research InstituteDepartment of Molecular Medicine, The Scripps Research InstituteDepartment of Biomedical and Pharmaceutical Sciences, University of MontanaThe repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural rationale for ligand bias in a nuclear receptor.https://doi.org/10.1038/s41467-019-13768-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zahra Heidari Ian M. Chrisman Michelle D. Nemetchek Scott J. Novick Anne-Laure Blayo Trey Patton Desiree E. Mendes Philippe Diaz Theodore M. Kamenecka Patrick R. Griffin Travis S. Hughes
spellingShingle	Zahra Heidari Ian M. Chrisman Michelle D. Nemetchek Scott J. Novick Anne-Laure Blayo Trey Patton Desiree E. Mendes Philippe Diaz Theodore M. Kamenecka Patrick R. Griffin Travis S. Hughes Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ Nature Communications
author_facet	Zahra Heidari Ian M. Chrisman Michelle D. Nemetchek Scott J. Novick Anne-Laure Blayo Trey Patton Desiree E. Mendes Philippe Diaz Theodore M. Kamenecka Patrick R. Griffin Travis S. Hughes
author_sort	Zahra Heidari
title	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_short	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_full	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_fullStr	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_full_unstemmed	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_sort	definition of functionally and structurally distinct repressive states in the nuclear receptor pparγ
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-12-01
description	The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural rationale for ligand bias in a nuclear receptor.
url	https://doi.org/10.1038/s41467-019-13768-0
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Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

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