FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

Skeletal muscle stem cells, or “satellite cells” (SCs), are required for the regeneration of damaged muscle tissue. Although SCs self-renew during regeneration, the mechanisms that govern SC re-entry into quiescence remain elusive. We show that FOXO3, a member of the forkhead family of transcription...

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Bibliographic Details
Main Authors: Suchitra D. Gopinath, Ashley E. Webb, Anne Brunet, Thomas A. Rando
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111400054X